Pathogenic role of oxidative and nitrosative stress in primary biliary cirrhosis

Figure 6 Aquaporin 8 is a specific water channel actively involved in the regulation of mitochondrial volume in the liver. Protein sulfhydryls (PSH) are a diffuse category of proteins playing important roles in mitochondria, including structural proteins and respiratory complexes to channel pores. The graph depicts the correlation between densitometric values of aquaporin 8 (AQP8) immunoreactivity and PSH content in the liver mitochondria of sham-operated and bile duct ligated rats at different time-points. AQP8 expression varies in relation to the changes in PSH content (n = 16, r = +0.96, r² = 0.913, P < 0.0001). N = 4 experiments per time point with 1 d, 3 d, 7 d and 10 d; BDL. Data adapted from Grattagliano and Portincasa (unpublished). Measurements performed as previously reported[65].