Increased susceptibility of aging gastric mucosa to injury: The mechanisms and clinical implications

Figure 12 Human relevance: expression of phosphatase and tensin homologue deleted on chromosome ten and survivin in gastric mucosa of young and aging individuals. A: Quantification of phosphatase and tensin homologue deleted on chromosome ten (PTEN)-positive cells in gastric mucosal sections demonstrated a significantly increased number and significantly increased mucosal area of positively stained cells, mainly epithelial cells in aging (≥ 70 years of age) vs young patients. The threshold of positive staining was set at level 75 on scale 0-255. Reproduced with permission from Tarnawski et al[1]; B: Photomicrographs of representative sections of human gastric mucosa of young and aging patients immunostained for survivin[1]. In gastric mucosa of young patients (40 years of age and younger), survivin expression is strong (brown-red staining) in the nuclei of the progenitor cells; C: Quantification of the number of positively stained cells for survivin demonstrated significantly reduced survivin expression in the gastric mucosa of aging patients (70 years of age or older) vs young patients as reflected by significantly fewer positively stained cells. Reproduced with permission from Tarnawski et al[1].