Increased susceptibility of aging gastric mucosa to injury: The mechanisms and clinical implications

doi:10.3748/wjg.v20.i16.4467

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Apr 28, 2014 (publication date) through Nov 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 28, 2014; 20(16): 4467-4482
Published online Apr 28, 2014. doi: 10.3748/wjg.v20.i16.4467

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Figure 7 Increased expression of early growth response-1 and increased early growth response-1 transcriptional activity in gastric mucosa of aging vs young rats. A: Representative Western blotting demonstrate increased early growth response-1 (egr-1) protein expression in gastric mucosa of aging (vs young) rats; B: Assessment of egr-1 transcriptional activity in gastric mucosa of young and aging rats was performed using the TranSignal™ TF-TF Interaction Array (Panomics, Redwood City, CA). The egr-1 cis-element is spotted in duplicate: in the first row DNA was spotted without dilution; in the second row DNA was diluted ten times (1:10). In gastric mucosa of aging rats there is a significant, 2.7-fold increase (vs that of young rats; P < 0.02) in binding of egr-1 protein to its GC-rich cis elements that are highly expressed in the PTEN gene promoter. Reproduced with permission from Tarnawski et al[1].

Citation: Tarnawski AS, Ahluwalia A, Jones MK. Increased susceptibility of aging gastric mucosa to injury: The mechanisms and clinical implications. World J Gastroenterol 2014; 20(16): 4467-4482
URL: https://www.wjgnet.com/1007-9327/full/v20/i16/4467.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i16.4467