Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis

Figure 4 Immunohistochemical findings of autoimmune hepatitis. CD3+ cells were found within the portal tract and in the periportal area (A), whereas CD38+ cells infiltrated prominently in the periportal area (B). IgG+ cells (C) and IgM+ cells (D) were also found in the periportal area, and IgG+ cell infiltration was predominant in the majority of autoimmune hepatitis cases. The distribution of these cells was similar to primary biliary cirrhosis (Figure 3); E: Double staining for IgG (red) and CD38 (green) showed that IgG-CD38 double positive cells, which may be IgG-producing plasma cells, were frequently seen in the periportal area (star). Original magnifications: × 200. Asterisk: Hepatic lobule.