Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis

Figure 3 β-catenin, tumour necrosis factor α receptors-I and II protein expression performed on peripheral blood cells and colon mucosa. A: Western blotting assay of β-catenin tumour necrosis factor α receptors-I (TNFRI) and TNFRII performed on protein extracts from peripheral blood cells. Familial adenomatous polyposis (FAP): Patient affected by adenomatous polyposis coli; PHTS: Patient affected by PTEN hamartoma tumour syndrome; I-1, I-2, II-1, II-2: Patient numbering corresponds to that adopted in the pedigree shown in Figure 1A. H1-5, H6-10: mixes of healthy subjects; B: Western blotting assay of β-catenin TNFRI and TNFRII performed on protein extracts from colon mucosa. FAP: Patient affected by adenomatous polyposis coli; colorectal cancer (CRC)1, CRC2, CRC3: Patients affected by sporadic colorectal mucosa; inflammatory bowel diseases (IBD): Affected proband; N: Healthy colon mucosa; T: Colon tumour; P: Colon polyp; I: Inflamed colon mucosa.