Quasispecies structure, cornerstone of hepatitis B virus infection: Mass sequencing approach

Figure 1 Overlapping region of the polymerase and surface genes (A) and its corresponding sequence (B). Translation into amino acids is depicted in blue in the P open reading frame (ORF) (above) and red in the S ORF (below). Most of the main codons related to nucleos(t)ide resistance (framed in blue), and the overlapping codons in the S ORF that may give rise to immune escape or stop codons (framed in red) are located within the fragment analyzed in a previous study by our group[58].