Characteristics and prognosis of gastric cancer in patients aged ≥ 70 years

Table 2 Survival analysis of all patients with gastric cancer after surgery

Characteristics	n (%)	5-yr OS	MST (mo)	Univariate analysis		Multivariate analysis
				χ2	P (log-rank)	Hazard ratio (95%CI)	P value
Gender				0.165	0.685
Male	659 (71.6)	32.00%	26
Female	261 (28.4)	33.70%	27
Age (yr)				21.067	< 0.000
< 50	166 (18.0)	38.00%	32			1 (ref)
50-69	481 (52.3)	36.60%	28			1.107 (0.881, 1.391)	0.383
≥ 70	273 (29.7)	22.00%	20			1.487 (1.149, 1.924)	0.003
Tumor location				37.996	< 0.001
Lower 1/3	372 (40.4)	40.10%	36			1 (ref)
Middle 1/3	166 (18.0)	30.10%	18			1.129 (0.881, 1.446)	0.339
Upper 1/3	270 (29.3)	29.60%	25			1.063 (0.864, 1.309)	0.564
2/3 or more	112 (12.2)	17.90%	16			1.311 (0.985, 1.744)	0.064
Tumor size				51.052	< 0.001
< 5 cm	375 (40.8)	45.10%	42			1 (ref)
≥ 5 cm	545 (59.2)	23.90%	20			1.185 (0.994, 1.413)	0.058
Borrmann type				9.588	0.002
I/II	308 (33.5)	38.30%	33			1 (ref)
III/IV	612 (66.5)	29.60%	23			1.171 (0.980, 1.399)	0.082
Histology				13.994	< 0.001
Differentiated	279 (30.3)	41.20%	34			1 (ref)
Undifferentiated	641 (69.7)	28.70%	23			1.201 (0.996, 1.449)	0.055
Extranodal metastasis				61.626	< 0.001
Negative	722 (78.5)	37.10%	31			1 (ref)
Positive	198 (21.5)	15.70%	15			1.164 (0.962, 1.409)	0.119
Surgical margin status				101.241	< 0.001
Negative	793 (86.2)	36.70%	31			1 (ref)
Positive	127 (13.8)	6.30%	11			1.705 (1.357, 2.142)	< 0.001
Depth of invasion				67.084	< 0.001
pT1	22 (2.4)	86.40%	69			1 (ref)
pT2	93 (10.1)	61.30%	61			3.048 (0.937, 9.918)	0.064
pT3	52 (5.7)	46.20%	47			3.188 (0.965, 10.526)	0.057
pT4	753 (81.8)	26.40%	21			4.580 (1.431, 14.200)	0.010
Lymph node metastasis				243.605	< 0.001
pN0	319 (34.7)	57.70%				1 (ref)
pN1	160 (17.4)	31.90%	24			1.713 (1.327, 2.211)	< 0.001
pN2	213 (23.2)	23.50%	23			1.918 (1.514, 2.429)	< 0.001
pN3	228 (24.8)	6.10%	13			3.268 (2.572, 4.151)	< 0.001
Distant metastasis				89.428	< 0.001
M0	855 (92.9)	34.70%	29			1 (ref)
M1	65 (7.1)	3.10%	8			1.817 (1.339, 2.465)	< 0.001
Chemotherapy				17.080	< 0.001
Yes	249 (27.1)	39.80%	37			1 (ref)
No	671 (72.9)	29.80%	22			1.383 (1.144, 1.673)	0.001
Type of gastrectomy				40.899	< 0.001
Subtotal	689 (73.9)	36.90%	31			1 (ref)
Total	231 (26.1)	19.50%	16			1.170 (0.944, 1.450)	0.151
Extent of lymphadenectomy				4.060	0.044
D2	402 (43.7)	36.60%	28			1 (ref)
D1	518 (56.3)	29.30%	24			1.192 (1.005, 1.414)	0.043

Ref: Reference category; OS: Overall survival; MST: Median survival time.