Role of bevacizumab in colorectal cancer growth and its adverse effects: A review

Figure 1 The process of angiogenesis and the mechanism of action of bevacizumab. A: The malignant cells secrete vascular endothelial growth factor (VEGF)-A; B: It is incorporated with its tyrosine kinase receptors (VEGFRs), promoting endothelial cell proliferation and migration; C: It leads to increased angiogenesis inducing tumor growth; D: Bevacizumab is combined with VEGF-A forming a new large molecule that lacks the ability to bind with its receptors; thus avoiding its incorporation and action, it then inhibits angiogenesis. Taken from Shord et al[15].