Role of microRNAs in the immune system, inflammation and cancer

Figure 1 Hypothetical model for the involvement of miR-196 in the pathogenesis of Crohn’s disease. MicroRNAs (miRNAs, miR) 196 normally targets immunity-related GTPase family, M (IRGM) mRNA within RNA-induced silencing complex (RISC) for a negative regulation (left panel). The IRGM risk allele (IRGM*) mRNA lacks the binding site for miR-196 and therefore is not regulated by this miRNA (right panel). During Crohn’s disease, loss of tight regulation of IRGM* expression by miR-196 may lead to defects in autophagy with most intracellular bacteria replication occurring in dysfunctional vacuoles[82] (dotted cycle). This consequently results in abnormal persistence of pathogens in host cells, which could further worsen disease status[82].