Quality of ulcer healing in gastrointestinal tract: Its pathophysiology and clinical relevance

Figure 4 Effect of low-dose indomethacin given during initial period of healing process of gastric ulcer induced by application of acetic acid in rats on cumulative remission rate after healing and on neutrophil infiltration of the interstitial space of the ulcer scar. Indomethacin treatment enhances neutrophil infiltration and this phenomenon persists even after cessation of this drug. Concomitant administration of 16, 16-dimethyl prostaglandin E2 (PGE2) with indomethacin reverses these effects by indomethacin. A: Cumulative remission rate after healing; B: Infiltration with polymorphonuclear cells during and after healing. Control; indomethacin; indomethacin + 16, 16-dimethyl prostaglandin E₂ (Arakawa et al[18]). ^aP < 0.05 vs control group.