Optical molecular imaging for detection of Barrett’s-associated neoplasia

Figure 4 In vivo localization of contrast agent localized to a neoplasia region visualized using wide-field fluorescence endoscopy. White light endoscopic image (A) shows no evidence of lesion; topical administration of peptide-targeted fluorescent dye reveals neoplastic area (B) [Copyright (2008), with permission from IOS Press][56]; targeted neoplastic crypts seen with fluorescence microscopy (C), and corresponding histology (D) [Copyright (2010), with permission from Elsevier][59].