Treatment of biliary tract cancer with NVP-AEW541: Mechanisms of action and resistance

Figure 5 In vitro treatment with drug combinations of NVP-AEW541 and gemcitabine, 5-fluorouracil (5-FU) or BI 2536. Selected cell lines EGI-1 and Mz-ChA-1 were incubated with increasing concentrations of gemcitabine (A, B), 5-FU (C, D) or BI 2536 (E, F) alone (black circles) and in combination with fixed IC₂₀ concentration of NVP-AEW541 (black triangles). The shaded area represents a possible drug synergism calculated according to the model of Berenbaum[50]; error bars represent SD (n = 3).