Magnetic resonance spectroscopy to study hepatic metabolism in diffuse liver diseases, diabetes and cancer

Figure 1 PME (A) and PDE (B) concentrations in the liver of healthy control subjects (n = 9) as well as weight-stable (n = 10) and weight-losing (n = 7) lung cancer patients during a primed-constant infusion of L-alanine (initial priming, 1. 4-2.8 mmol/kg; infusion, 2.8 mmol/kg per hour). Curves represent means; bars, SE. Values are expressed as percentage of mean baseline value of healthy subjects (100%). Times during L-alanine infusion are mid-time points of 31P MRS data collection referenced to the start of the L-alanine infusion (0 = baseline). From[50], with permission.