Risk for colorectal cancer in ulcerative colitis: Changes, causes and management strategies

Figure 1 Summary of geneticalte-rations in sporadic colorectal cancer (A) and colitis-associated colorectal cancer (B). The timing of p53 and APC mutations is different; unlike in sporadic neoplasia, mutations and LOH in p53 are early events in UC-associated CRCs. The opposite was reported for APC mutations[42].