Hepatic reconstruction from fetal porcine liver cells using a radial flow bioreactor

Figure 1 The principle of RFB system. A: A cylindrical bioreactor is filled with porous cellulose beads that act as microcarriers and culture medium flows from the periphery toward the center of the reactor. Biases in distribution of oxygen and nutrients between the culture medium at the inlet and outlet of the reactor are minimized; B: The RFB system is similar to the organization of the hepatic primary lobe Figure 1B is reproduced from reference 7.