Genome-wide differences in hepatitis C- vs alcoholism-associated hepatocellular carcinoma

Figure 3 Etiology-dependent clustering of tumors only, with (tumor/controls) ratios. A: Selection of transcripts with a significantly abnormal (level in tumor/mean level in controls) ratio. Black + red dots: 2641 transcripts with an abnormal ratio in at least 1/22 patients. Red dots: SAM selection of 18 informative transcripts (22 probes) with a significantly increased (tumor/controls) ratio in alcoholic vs HCV patients. SAM parameters as in Figure 2; B: UHC of 5 control livers and 22 tumors from 22 HCC patients, as done with the data of the 18 informative transcripts selected in A; The stars point to 15 transcripts (19 probes) that also belonged to the set of 23 transcripts previously selected in Figure 2; C: Selection of transcripts with a significantly abnormal (level in cirrhosis/mean level in controls) ratio. Black dots: 2037 transcripts with an abnormal ratio in at least 1/22 patients. No informative transcript was selected by SAM (no red dot); D: UHC of 5 control patients and 22 HCC-associated cirrhotic samples from 22 HCC patients, as done with the list of 18 transcripts used in B. Other details as in Figure 2.