Genome-wide differences in hepatitis C- vs alcoholism-associated hepatocellular carcinoma

Figure 1 Etiology-dependent location of dysregulated genes. A total of 475 genes (HCV, 301 genes; alcoholism, 174 genes) with a dysregulated transcript were studied. Dysregulated transcripts were defined by an abnormal (tumor/cirrhosis) ratio in at least 3 patients of at least one etiology group (see details in Table 2, footnote 3). The number of dysregulated genes per chromosome is expressed as a percentage of the total number of dysregulated genes per etiology. Significant differences of gene frequency on a given chromosome in HCV vs alcoholic patients are: chr 2, P = 0.004; chr 8, P = 0.02 (Chi square test with Yates’ correction), ^aP≤ 0.02.