Protective effects of medical ozone combined with traditional Chinese medicine against chemically-induced hepatic injury in dogs

Table 1 Histological assessment of drug induced acute hepatitis in dogs

Score	Centrilobular necrosis	Inflammation in centrilobular areas
0	None	None
1	Isolated necrotic hepatocytes or single row of hepatocyte drop-out in perivenular areas	Mild: inflammatory infiltrate affecting < 50% centrilobular areas
2	> 1 and up to 3 rows of perivenular necrotic hepatocytes	Moderate: inflammatory infiltrate affecting > 50% and < 75% centrilobular areas
3	> 3 rows of perivenular necrotic hepatocytes with confluent and/or bridging necrosis	Severe: dense inflammatory infiltrate affecting > 75% centrilobular areas