Genetic epidemiology of primary sclerosing cholangitis

Figure 3 Schematic outline of the HLA complex on chromosome 6. Distances are arbitrary. By convention, the extended HLA complex stretches from the centromeric border of the HLA class II loci (HLA-DP) to the telomeric limit of the histone gene cluster more than 4 million bp from HLA-A[43,120]. Centromeric to the HLA-DQ loci, a region with intense recombination can be found ("recombination hot-spot")[132].