In situ tumor vaccination with adenovirus vectors encoding measles virus fusogenic membrane proteins and cytokines

Figure 3 Effect of indicated treatments on the spleen weight and infiltration of tumors with macrophages. Treatment was carried out as described in Figure 2. A: At d 29 animals were euthanized and spleen weight was determined (mean ± SD); B: The spleens of representative mice of different treatment groups are shown; C: In addition, fourteen days after initiation of therapy continous serial sections of the directly and not directly vector treated tumors of spare animals were prepared and individually immunostained for indicated cells. Representative slides are shown; original magnification × 400. Similar data were obtained in the Colon26 tumor model (data not shown).