Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis

Figure 8 Differential regulations of genes involved in key events of liver fibrosis. Gene expression profiles of different events in liver fibrogenesis such as ECM synthesis/degradation, inflammation and oxidative stress, are shown. The x-axis showing the days of fibrogenesis (d 0, 4, 7 14, 21, 28) and the y-axis the normalized log ratio(scaled in terms of mean and SD, and the log base 2) of the whole liver gene expression. A and B: genes of ECM synthesis/degradation classified into group 1 (2) of HSCs as shown in Figure 2; C: genes of inflammation involved in the Kupffer cell fraction as shown in Figure 4; D: genes of oxidative stress involved in the hepatocytes as shown in Figure 6.