Complementary analysis of microsatellite tumor profile and mismatch repair defects in colorectal carcinomas

Figure 1 Microsatellite unstable CRCs are normally located proximal to the splenic flexure and reveal non-polypoid pattern. MSI can be demonstrated by fluorescence in-situ hybridization (FISH) or molecular techniques. Histopathologically, these tumors show solid growth, mucinous differentiation, prominent lymphocytic infiltrate, and no dirty necrosis[10].