Role of N-acetylcysteine in rifampicin-induced hepatic injury of young rats

Table 3 Effect of RMP treatment (50 mg/kg/day for 3 wk) and NAC (100 mg/kg/day for 3 wk) on glutathione peroxidase, glutathione reductase and cytochrome P₄₅₀ (nmol/min/mg protein) (mean±SD)

Group	Glutathioneperoxidase	Glutathionereductase	Cytochrome P450
Control (C)	458.37±45.19	25.37±3.82	0.431±0.050
RMP	287.18±39.82Wb	27.01±2.75	0.540±0.039b
RMP + NAC	385.99±50.47a	27.47±3.27	0.509±0.042a
NAC	474.07±37.92	26.93±4.01	0.412±0.047

^aP < 0.05 vs control, ^bP < 0.001 vs control.