Role of N-acetylcysteine in rifampicin-induced hepatic injury of young rats

doi:10.3748/wjg.v12.i2.287

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Jan 14, 2006 (publication date) through May 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2006; 12(2): 287-291
Published online Jan 14, 2006. doi: 10.3748/wjg.v12.i2.287

Role of N-acetylcysteine in rifampicin-induced hepatic injury of young rats

SV Rana, S Attri, K Vaiphei, R Pal, A Attri, K Singh

SV Rana, S Attri, R Pal, K Singh, Department of Gastr-oenterology, Postgraduate Institute of Medical Education and Research, Chandigarh-160012, India

K Vaiphei, Department of Palhotogy, Postgraduate Institute of Medical Education and Research, Chandigarh-160012, India.

A Attri, Department of Surgery, Govt. Medical College, Cha-ndigarh-160012, India

Supported by Department of Science and Technology, Changdigarh, India

Correspondence to: Dr. SV Rana, Professor, Department of Gastroenterology, House No. 137, Sector 15-A, Chandigarh, India. svrana25@hotmail.com

Telephone: 0091-172-2744401

Received: May 29, 2005
Revised: June 28, 2005
Accepted: July 1, 2005
Published online: January 14, 2006

Abstract

AIM: To study the role of N-acetylcysteine (NAC) as a protective agent in rifampicin (RMP)-induced oxidative hepatic injury of young rats.

METHODS: Hepatic injury was produced by giving 50mg/kg body weight/day of RMP for 3 wk. A dose of NAC (100mg/kg body weight/day) was given in combination with RMP intraperitoneally. Analysis of lipid peroxidation, thiol levels, cytochrome P₄₅₀, superoxide dismutase (SOD), catalase, glutathione peroxidase, reductase and transferase were estimated in liver along with the body weight, liver weight and histological observations.

RESULTS: RMP exposure resulted in no change in body and liver weight while antioxidative enzymes were altered but the non protein thiol (GSH) status was well preserved. Cytochrome P₄₅₀ system and peroxidation of lipids were induced by RMP exposure. Partial protection was observed with NAC against RMP-induced changes in liver, which was evidenced from the prevention of increase in lipid peroxidation and the reduction in SOD and catalase enzyme levels.

CONCLUSION: NAC protects young rats against RMP-induced oxidative hepatic injury.

Keywords: Rifampicin, N-acetylcysteine, Hepa-toprotection.