Role of N-acetylcysteine in rifampicin-induced hepatic injury of young rats

Table 1 Effect of RMP treatment (50 mg/kg/day for 3 wk) and NAC (100 mg/kg/day for 3 wk) on total, protein-bound and non-protein thiols in rats (µmole /g liver) (mean±SD)

Group	Total thiols	Protein bound	Non protein thiols(GSH)
Control	13.42 ± 0.52	10.09 ± 0.45	3.23 ± 0.42
RMP	16.77 ± 0.61a	13.49 ± 0.42a	2.98 ± 0.61
RMP + NAC	17.17 ± 0.78b	13.92 ± 0.51b	3.37 ± 0.72
NAC	13.44 ± 0.50	9.55 ± 0.25	3.42 ± 0.43

^aP < 0.05 vs control, ^bP < 0.001 vs control.