Relaxin prevents the development of severe acute pancreatitis

Figure 1 BPDOE-CDL model to trigger acute pancreatitis. Two closed-duodenal-loops were created in such a way that the entrance of the common bilio-pancreatic duct-outlet was absolutely excluded. To double check the absence of duodenal-reflux content or duodenal leakage, methylene blue was added to the sodium tauracholate which was instilled into the peri-vaterian duodenum through the superior and inferior holes (reproduced with permission granted by the Journal of Pancreatology and S. Karger AG, Basel)[6].