Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer

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Jul 7, 2005 (publication date) through Jan 13, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Gastric Cancer

World J Gastroenterol. Jul 7, 2005; 11(25): 3834-3841
Published online Jul 7, 2005. doi: 10.3748/wjg.v11.i25.3834

Table 7 Frequencies of mutations of the p53 and Ki-ras genes, and microsatellite instability according to hMLH1 promoter hypermethylation

Gene	hMLH1 promoter hypermethylation		OR¹ (95%CI²)	χ²	P
Gene	Yes (%)	No (%)		χ²	P
P53			OR¹ (95%CI²)
No	31 (81.58)	46 (65.71)	1.00	4.199	0.041
Yes	7 (18.42)	24 (34.29)	0.34 (0.12 – 0.95)
Ki-ras
No	37 (97.37)	58 (93.55)	1.00	0.407	0.524
Yes	1 (2.63)	4 (6.45)	0.47 (0.05 – 4.72)
³MSI
No	28 (73.68)	66 (92.86)	1.00	7.458	0.006
Yes	10 (26.32)	4 (7.14)	6.19 (1.67 – 22.88)

¹Odds ratio was adjusted for age and sex.

²Confidence interval.

³Microsatellite instability.

Citation: Nan HM, Song YJ, Yun HY, Park JS, Kim H. Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer. World J Gastroenterol 2005; 11(25): 3834-3841
URL: https://www.wjgnet.com/1007-9327/full/v11/i25/3834.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i25.3834