Advancements in medical treatment for pancreatic neuroendocrine tumors: A beacon of hope

doi:10.3748/wjg.v30.i12.1670

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Mar 28, 2024 (publication date) through Jun 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2024; 30(12): 1670-1675
Published online Mar 28, 2024. doi: 10.3748/wjg.v30.i12.1670

Advancements in medical treatment for pancreatic neuroendocrine tumors: A beacon of hope

Somdatta Giri, Jayaprakash Sahoo

Somdatta Giri, Jayaprakash Sahoo, Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006, India

Author contributions: Giri S did the literature search, wrote the first draft and gave intellectual input; Sahoo J conceptualized the work, supervised the writing, gave intellectual inputs, and critically revised the manuscript.

Conflict-of-interest statement: All authors have no conflict of interest to report.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Jayaprakash Sahoo, MBBS, MD, DM, Full Professor, Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research, D. Nagar, Gorimedu, JIPMER Campus, Puducherry 605006, India. jppgi@yahoo.com

Received: December 28, 2023
Peer-review started: December 28, 2023
First decision: January 19, 2024
Revised: January 29, 2024
Accepted: March 7, 2024
Article in press: March 7, 2024
Published online: March 28, 2024

Core Tip

Core Tip: The evolving landscape of pancreatic neuroendocrine tumor treatment showcases tailored approaches based on tumor subtype. Cytoreductive surgery and somatostatin analogs are pivotal, whereas peptide receptor radionuclide therapy and molecular targeted agents are offering hope for refractory cases. Understanding genetic markers and exploring immunotherapies open promising avenues for future research.