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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2023; 29(6): 1076-1089
Published online Feb 14, 2023. doi: 10.3748/wjg.v29.i6.1076
Published online Feb 14, 2023. doi: 10.3748/wjg.v29.i6.1076
Clinical-radiomics nomogram for predicting esophagogastric variceal bleeding risk noninvasively in patients with cirrhosis
Rui Luo, Jian Gao, Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, Chongqing, China
Wei Gan, Wei-Bo Xie, Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, Chongqing, China
Author contributions: Luo R was responsible for designing the study, collecting data, analyzing data, and writing the paper; Gao J was responsible for designing the study and guiding important content of the article; Gan W and Xie WB were responsible for providing technical support. All authors approved the final version of the manuscript for submission for publication.
Supported by Kuanren Talents Program of The Second Affiliated Hospital of Chongqing Medical University.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of the Second Affiliated Hospital of Chongqing Medical University (No. 2022-149).
Informed consent statement: Our study was a retrospective study conducted at a single center. We used data from patients at the time they were treated in the hospital, and these data were collected and analyzed anonymously. The informed consent waiver was granted by the Institutional Review Board.
Conflict-of-interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian Gao, MMed, PhD, Chief Doctor, Professor, Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, Yuzhong District, Chongqing 400010, Chongqing, China. gaojian@cqmu.edu.cn
Received: October 14, 2022
Peer-review started: October 14, 2022
First decision: December 1, 2022
Revised: December 13, 2022
Accepted: January 29, 2023
Article in press: January 29, 2023
Published online: February 14, 2023
Peer-review started: October 14, 2022
First decision: December 1, 2022
Revised: December 13, 2022
Accepted: January 29, 2023
Article in press: January 29, 2023
Published online: February 14, 2023
Core Tip
Core Tip: Esophagogastric variceal bleeding (EGVB) is a life-threatening complication of liver cirrhosis. Currently, no noninvasive prediction models for bleeding risk are widely used in clinical practice. Our study extracted radiomics features from computed tomography and identified portal vein thrombosis, fibrinogen, aspartate aminotransferase, albumin, and spleen thickness as independent clinical predictors. Consequently, we established a novel clinical-radiomics model for noninvasive prediction of EGVB. This model exhibits superior diagnostic performance and can assess bleeding risk early. It has the potential to facilitate early prevention and treatment of possible bleeding in cirrhotic patients with esophagogastric varices.