Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2023; 29(43): 5848-5864
Published online Nov 21, 2023. doi: 10.3748/wjg.v29.i43.5848
Chemical components and protective effects of Atractylodes japonica Koidz. ex Kitam against acetic acid-induced gastric ulcer in rats
Bi-Xian Zhen, Qian Cai, Feng Li
Bi-Xian Zhen, Qian Cai, Feng Li, Department of Medicine, Liaoning University of Traditional Chinese Medicine, Dalian 116600, Liaoning Province, China
Author contributions: Li F and Cai Q designed the experiment; Zhen BX completed the whole experiment and wrote the manuscript; and all authors approved the final version of the article.
Supported by National Natural Science Foundation of China, No. 81973478; Liaoning Revitalization Talents Program, China, No. XLYC2002004; and Natural Science Foundation of Liaoning Province, China, No. 2019-ZD-0443.
Institutional animal care and use committee statement: The Laboratory Animal Center and Animal Care & Welfare Committee of Liaoning University of TCM approved the animal experiments.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng Li, PhD, Professor, Department of Medicine, Liaoning University of Traditional Chinese Medicine, No. 77 Shengming 1st Road, Double D Port, Dalian 116600, Liaoning Province, China. zhanglijiayi@163.com
Received: August 30, 2023
Peer-review started: August 30, 2023
First decision: October 8, 2023
Revised: October 21, 2023
Accepted: November 7, 2023
Article in press: November 7, 2023
Published online: November 21, 2023
Core Tip

Core Tip:Atractylodes japonica Koidz. ex Kitam. is a commonly used folk medicine for the treatment of gastric ulcer (GU), but the mechanism of the treatment of GU is still unclear. In this study, chemical composition, pharmacodynamics and metabolomics were studied to explore the potential mechanism of it. The finding was closely related to anti-inflammation, ulcer healing and other factors.