Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2023; 29(34): 5038-5053
Published online Sep 14, 2023. doi: 10.3748/wjg.v29.i34.5038
Suberoylanilide hydroxamic acid upregulates reticulophagy receptor expression and promotes cell death in hepatocellular carcinoma cells
Jia-Yao Li, Tian Tian, Bing Han, Ting Yang, Yi-Xin Guo, Jia-Yu Wu, Yu-Si Chen, Qin Yang, Ru-Jia Xie
Jia-Yao Li, Bing Han, Ting Yang, Yi-Xin Guo, Jia-Yu Wu, Yu-Si Chen, Qin Yang, Ru-Jia Xie, Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, College of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, Guizhou Province, China
Jia-Yao Li, Bing Han, Ting Yang, Yi-Xin Guo, Jia-Yu Wu, Yu-Si Chen, Qin Yang, Ru-Jia Xie, Department of Pathophysiology, College of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, Guizhou Province, China
Tian Tian, Department of Eugenic Genetics, Guiyang Maternal and Child Health Care Hospital, Guiyang 550003, Guizhou Province, China
Author contributions: Xie RJ and Yang Q contributed to the experimental conception and design; Li JY, Tian T, and Han B conducted the experiments; Yang T and Guo YX collected and assembled the experimental data; Li JY, Chen YS, and Wu JY contributed to data analysis and interpretation; Li JY and Xie RJ wrote the article; All authors approved the final manuscript. Li JY, Tian T, and Han B contributed equally to this work.
Supported by the National Natural Science Foundation of China, No. 82260127; Guizhou Provincial Science and Technology Projects, No. Qiankehe Jichu-ZK[2021]365 and Qiankehe Jichu-ZK[2021]364; National Natural Science Foundation Cultivation Project of Guizhou Medical University, No. 20NSP016; Guizhou Provincial Natural Science Foundation, No. [2021]4029 and [2022]4017; and Science and Technology Foundation of Guizhou Provincial Health Commission, No. gzwjkj2019-1-102.
Institutional review board statement: This study did not involve human subjects or living animals.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
Data sharing statement: The data used to support the findings of this study are available from the corresponding author at 592153968@qq.com upon request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ru-Jia Xie, MD, Academic Research, Department of Pathophysiology, College of Basic Medical Sciences, Guizhou Medical University, Dongqing Road, Guiyang 550025, Guizhou Province, China. 592153968@qq.com
Received: March 23, 2023
Peer-review started: March 23, 2023
First decision: June 17, 2023
Revised: July 15, 2023
Accepted: August 15, 2023
Article in press: August 15, 2023
Published online: September 14, 2023
Core Tip

Core Tip: Family with sequence similarity 134 member B (FAM134B) is considered to be a tumor suppressor protein that can play a pivotal role in inhibiting hepatocellular carcinoma (HCC) cells. In addition, FAM134B acts as a putative reticulophagy receptor in the regulation of the reticulophagy process. Furthermore, suberoylanilide hydroxamic acid (SAHA) upregulates FAM134B expression in HCC cells and promotes apoptosis and autophagy-mediated cell death. Thus, FAM134B-mediated reticulophagy synergizes with SAHA to induce HCC cell death. Our findings offer novel insights into the mechanism underlying SAHA-induced HCC cell death.