Retrospective Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 7, 2019; 25(37): 5667-5675
Published online Oct 7, 2019. doi: 10.3748/wjg.v25.i37.5667
Soluble mannose receptor as a predictor of prognosis of hepatitis B virus-related acute-on-chronic liver failure
Tai-Ping Li, Shi-He Guan, Qin Wang, Li-Wen Chen, Kai Yang, Hao Zhang
Tai-Ping Li, Shi-He Guan, Qin Wang, Li-Wen Chen, Kai Yang, Hao Zhang, Department of Clinical Laboratory, The Second Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China
Author contributions: Li TP acquired the data and drafted the manuscript; Li TP and Wang Q collected clinical samples and performed in vitro experiments; Li TP, Wang Q, and Chen LW analyzed the data; Yang K and Zhang H performed statistical analysis; Guan SH reviewed the manuscript, figures, and tables.
Supported by the Class A Project of the Key Research and Development Programs of the Science and Technology Department of Anhui Province, No. 1804h08020236; and the Key Project of the Natural Science Foundation of Anhui Province, No. KJ2018A0206.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Second Hospital of Anhui Medical University.
Informed consent statement: All study participants provided written informed consent prior to study enrolment.
Conflict-of-interest statement: There are no potential conflicts of interest relevant to this article to be reported.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shi-He Guan, MD, PhD, Full Professor, Department of Clinical Laboratory, The Second Hospital of Anhui Medical University, Furong Road 678#, Hefei 230601, Anhui Province, China. shiheguan@126.com
Telephone: +86-551-63869508 Fax: +86-551-63869400
Received: July 15, 2019
Peer-review started: July 16, 2019
First decision: August 2, 2019
Revised: August 21, 2019
Accepted: September 11, 2019
Article in press: September 11, 2019
Published online: October 7, 2019
Core Tip

Core tip: This is a retrospective study to evaluate the value of soluble mannose receptor (sMR) level for predicting the 90-day mortality of patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). Serum sMR level was significantly higher in patients with HBV-ACLF, and it was an independent risk factor associated with the prognosis of HBV-ACLF. Furthermore, sMR level significantly improved the performance of model for end-stage liver disease score for predicting the prognosis of HBV-ACLF patients.