Sagnelli C, Pisaturo M, Calò F, Martini S, Sagnelli E, Coppola N. Reactivation of hepatitis B virus infection in patients with hemo-lymphoproliferative diseases, and its prevention. World J Gastroenterol 2019; 25(26): 3299-3312 [PMID: 31341357 DOI: 10.3748/wjg.v25.i26.3299]
Corresponding Author of This Article
Caterina Sagnelli, MD, PhD, Associate Professor, Chief Doctor, Reader (Associate Professor), Department of Mental Health and Public Medicine, Section of Infectious Diseases, University of Campania Luigi Vanvitelli, Via L. Armanni 5, Naples 80127, Italy. sagnelli.caterina@libero.it
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Caterina Sagnelli, Mariantonietta Pisaturo, Federica Calò, Salvatore Martini, Evangelista Sagnelli, Nicola Coppola, Department of Mental Health and Public Medicine, Section of Infectious Diseases, University of Campania Luigi Vanvitelli, Naples 80127, Italy
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: All the authors of the manuscript declare that they have no conflict of interest regarding this paper.
Open-Access: This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Caterina Sagnelli, MD, PhD, Associate Professor, Chief Doctor, Reader (Associate Professor), Department of Mental Health and Public Medicine, Section of Infectious Diseases, University of Campania Luigi Vanvitelli, Via L. Armanni 5, Naples 80127, Italy. sagnelli.caterina@libero.it
Telephone: +39-81-5666719 Fax: +39-81-5666207
Received: March 17, 2019 Peer-review started: March 18, 2019 First decision: April 16, 2019 Revised: May 10, 2019 Accepted: May 18, 2019 Article in press: May 18, 2019 Published online: July 14, 2019
Core Tip
Core tip: Hepatitis B virus (HBV) reactivation frequently exerts a negative impact on the outcome of patients with hemo-lymphoproliferative disorders both by liver injury, at times severe, and a premature delay or termination of immunosuppressive treatments. Patients at risk should be identified by screening of HBV serum markers before immunosuppressive therapy is started. The use of HBV nucle(t)side analogues, as treatment or prophylaxis, is effective in limiting the frequency and intensity of the damage caused. Antivirals should be administered 2-3 wk before starting immunosuppressive treatment, for the entire immunosuppressive period and during post-treatment follow-up, the length of which depends on the intensity of immunosuppression reached.
