Retrospective Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 28, 2016; 22(48): 10617-10624
Published online Dec 28, 2016. doi: 10.3748/wjg.v22.i48.10617
Assessment of disease activity by fecal immunochemical test in ulcerative colitis
Dae Gon Ryu, Hyung Wook Kim, Su Bum Park, Dae Hwan Kang, Cheol Woong Choi, Su Jin Kim, Hyeong Seok Nam
Dae Gon Ryu, Hyung Wook Kim, Su Bum Park, Dae Hwan Kang, Cheol Woong Choi, Su Jin Kim, Hyeong Seok Nam, Department of Internal Medicine, Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, South Korea
Author contributions: Ryu DG wrote the manuscript; Kim HW organized the manuscript; Park SB, Kang DH, Choi CW, Kim SJ and Nam HS contributed to the design, organization, and draft of the manuscript; all authors read and approved the final manuscript.
Supported by a 2-Year Research Grant of Pusan National University.
Conflict-of-interest statement: No potential conflict of interest relevant to this article was reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hyung Wook Kim, PhD, MD, Department of Internal Medicine, Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, 20, Geumo-ro, Mulgeum-eup, Yangsan 626-770, Gyeongsangnam-do, South Korea. mdkhwook@gamil.com
Telephone: +82-55-3601535 Fax: +82-55-3601536
Received: July 18, 2016
Peer-review started: July 21, 2016
First decision: October 11, 2016
Revised: October 15, 2016
Accepted: November 15, 2016
Article in press: November 16, 2016
Published online: December 28, 2016
Processing time: 161 Days and 15.3 Hours
Core Tip

Core tip: Until now, colonoscopy has been regarded as the gold standard to assess mucosal status and disease activity in patients with ulcerative colitis (UC). Recently, non-invasive markers of mucosal healing have been studied in UC. Fecal immunochemical test (FIT) is one of them suggested association with mucosa healing in some studies. Our results have identified that FIT correlated positively with endoscopic activity and clinical remission, but not with extent of disease. In particular a negative FIT could be regarded as an indication of endoscopic and clinical remission. FIT can be a non-invasive and economic biomarker in patients with UC.