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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2015; 21(9): 2777-2785
Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2777
Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2777
Prolonged overall survival in gastric cancer patients after adoptive immunotherapy
Guo-Qing Zhang, Hong Zhao, Jian-Yu Wu, Jin-Yu Li, Xiang Yan, Shun-Chang Jiao, Department of Clinical Oncology, Chinese PLA General Hospital, Beijing 100853, China
Gang Wang, Liang-Liang Wu, Laboratory of Tumor Research Center, Chinese PLA General Hospital, Beijing 100853, China
Xiao-Gang Zhang, Yi Shao, Yu Wang, Beijing Immunotech Applied Science Limited, Beijing 101111, China
Author contributions: Zhang GQ and Zhao H contributed equally to this work; Zhang GQ contributed to study design, writing and revision of the manuscript; Zhao H contributed to the patient enrollment and data analysis; Jiao SC contributed to study conception and design, critical revision of the manuscript, and financial support prior to publication; Wu JY, Li JY and Yan X contributed to patient enrollment; Wang G, Wu LL and Zhang XG analyzed the lymphocyte subtypes; Shao Y and Wang Y prepared EAAL samples; and all authors have read and approved the final manuscript.
Supported by National Science and Technology Infrastructure Program of China, No. 2009BAI86B05.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shun-Chang Jiao, MD, PhD, Department of Clinical Oncology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China. medscijsc@126.com
Telephone: +86-10-66937261 Fax: +86-10-68238924
Received: June 23, 2014
Peer-review started: June 24, 2014
First decision: August 6, 2014
Revised: September 4, 2014
Accepted: November 18, 2014
Article in press: November 19, 2014
Published online: March 7, 2015
Peer-review started: June 24, 2014
First decision: August 6, 2014
Revised: September 4, 2014
Accepted: November 18, 2014
Article in press: November 19, 2014
Published online: March 7, 2015
Core Tip
Core tip: We undertook a retrospective analysis of patients with gastric cancer to perform an observational study on whether expanded activated autologous lymphocytes (EAALs) improved treatment outcomes. The results provide the first evidence for EAALs being an effective treatment regimen in gastric cancer. The therapy was straightforward and showed good safety, and overall survival may be improved with EAAL treatment in gastric cancer patients.