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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2015; 21(9): 2645-2650
Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2645
Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2645
Angiopoietin and vascular endothelial growth factor expression in colorectal disease models
Wei-Xin Liu, Shen Zhang, Yi Ren, Li-Xuan Sang, Cong Dai, Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China
Shou-Zhi Gu, Department of Anatomy, Seirei Christopher College, Hamamatsu 433-8558, Japan
Author contributions: Liu WX and Gu SZ designed the research; Zhang S, Ren Y, Sang LX and Dai C performed the research; Liu WX, Gu SZ and Dai C analyzed the data; Liu WX and Gu SZ wrote the paper.
Supported by Science and Technology Project of Liaoning Province, No. 2013225303; and the Science and Technology Project of Shenyang City, No. F13-316-1-40.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Wei-Xin Liu, Professor, Department of Gastroenterology, First Affiliated Hospital, China Medical University, No. 155 North Nanjing Street, Heping District, Shenyang 110001, Liaoning Province, China. weixinliu@yahoo.com
Telephone: +86-24-83282863 Fax: +86-24-83282863
Received: September 20, 2014
Peer-review started: September 21, 2014
First decision: October 14, 2014
Revised: November 6, 2014
Accepted: December 5, 2014
Article in press: December 8, 2014
Published online: March 7, 2015
Peer-review started: September 21, 2014
First decision: October 14, 2014
Revised: November 6, 2014
Accepted: December 5, 2014
Article in press: December 8, 2014
Published online: March 7, 2015
Core Tip
Core tip: Colorectal cancer is the most severe complication in ulcerative colitis. Angiopoietin (Ang)-1, Ang-2, their receptor, tyrosine kinase with immunoglobulin-like and EGF-like domains (Tie)-2, and vascular endothelial growth factor may play a key role in forming vasculature which is involved in carcinogenesis. In this study, rats with ulcerative colitis and colorectal cancer had increased expression of these proteins, which suggests they may contribute to the development of colon cancer, chronic colitis, and pathologic angiogenesis in the rat.