Ihnát P, Vávra P, Zonča P. Treatment strategies for colorectal carcinoma with synchronous liver metastases: Which way to go? World J Gastroenterol 2015; 21(22): 7014-7021 [PMID: 26078580 DOI: 10.3748/wjg.v21.i22.7014]
Corresponding Author of This Article
Peter Ihnát, MD, PhD, MBA, Department of Surgical Studies, Faculty of Medicine, University of Ostrava, Syllabova 19, Ostrava 70300, Czech Republic. peterihnat@yahoo.com
Research Domain of This Article
Surgery
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jun 14, 2015; 21(22): 7014-7021 Published online Jun 14, 2015. doi: 10.3748/wjg.v21.i22.7014
Treatment strategies for colorectal carcinoma with synchronous liver metastases: Which way to go?
Peter Ihnát, Petr Vávra, Pavel Zonča
Peter Ihnát, Petr Vávra, Pavel Zonča, Department of Surgical Studies, Faculty of Medicine, University of Ostrava, Ostrava 70300, Czech Republic
Peter Ihnát, Petr Vávra, Pavel Zonča, Department of Surgery, University Hospital Ostrava, Ostrava 70852, Czech Republic
Author contributions: Ihnát P and Zonča P performed the literature search; Ihnát P and Vávra P wrote the paper; Zonča P revised the paper.
Conflict-of-interest: All authors declare that they have no personal, political or financial conflicts of interest.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Peter Ihnát, MD, PhD, MBA, Department of Surgical Studies, Faculty of Medicine, University of Ostrava, Syllabova 19, Ostrava 70300, Czech Republic. peterihnat@yahoo.com
Telephone: + 42-597-375701 Fax: + 42-597-375054
Received: December 28, 2014 Peer-review started: December 29, 2014 First decision: January 22, 2015 Revised: February 6, 2015 Accepted: April 3, 2015 Article in press: April 3, 2015 Published online: June 14, 2015
Core Tip
Core tip: There are four treatment strategies available for synchronous liver metastases of colorectal carcinoma (CLM): (1) primary first approach comprises resection of the primary colorectal tumor followed by chemotherapy and liver resection; (2) simultaneous resection of liver and colorectal primary tumor; (3) liver-first (or chemotherapy-first) approach comprises preoperative chemotherapy, liver resection, adjuvant chemotherapy, and resection of the primary colorectal tumor (best for asymptomatic primary tumors and initially unresectable or marginally resectable CLM); and (4) up-front hepatectomy (or “true” liver-first approach) includes liver resection followed by adjuvant chemotherapy and colorectal resection (for asymptomatic primary tumors and initially resectable CLM).
