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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2015; 21(2): 667-674
Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.667
Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.667
Biopathologic features and clinical significance of micrometatasis in the lymph node of early gastric cancer
Min Jung Jo, Ji Yeon Park, Myeong-Cherl Kook, Keun Won Ryu, Soo-Jeong Cho, Jun Ho Lee, Il Ju Choi, Young-Woo Kim, Gastric Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang-si 410-769, South Korea
Joon Seon Song, Eun Kyung Hong, Department of Pathology, Research Institute and Hospital, National Cancer Center, Goyang-si 410-769, South Korea
Byung-Ho Nam, Cancer Registration and Biostatistics Branch and Center for Clinical Trial, National Cancer Center, Goyang-si 410-769, South Korea
Author contributions: Jo MJ and Park JY contributed equally to this work; Ryu KW designed the research; Jo MJ, Song JS, Cho SJ, Lee JH, Choi IJ and Kim YW performed the research; Ryu KW, Kook MC, Hong EK and Nam BH analyzed the data; Ryu KW, Jo MJ and Park JY wrote the paper.
Supported by Grants from the National Cancer Center, Republic of Korea, Grant No. 0910560-1 and No. 1010490-1.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Eun Kyung Hong, MD, Department of Pathology, Research Institute and Hospital, National Cancer Center, 809 Madu1-dong, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-769, South Korea. hongek@ncc.re.kr
Telephone: +82-31-9201628 Fax: +82-31-9200069
Received: June 12, 2014
Peer-review started: June 13, 2014
First decision: July 9, 2014
Revised: July 16, 2014
Accepted: July 24, 2014
Article in press: July 25, 2014
Published online: January 14, 2015
Peer-review started: June 13, 2014
First decision: July 9, 2014
Revised: July 16, 2014
Accepted: July 24, 2014
Article in press: July 25, 2014
Published online: January 14, 2015
Core Tip
Core tip: Nodal micrometastasis in early gastric cancer (EGC) has a relatively high proliferative and an equivalent apoptotic activities compared to other cancers. The incidence of Japanese N2 station micrometastasis involvement is about 10%. Lymphadenectomy of D1+β or more might be necessary if micrometastasis is identified during sentinel node biopsy in EGC.