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©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Feb 21, 2014; 20(7): 1667-1680
Published online Feb 21, 2014. doi: 10.3748/wjg.v20.i7.1667
Published online Feb 21, 2014. doi: 10.3748/wjg.v20.i7.1667
Role of the tumor microenvironment in the pathogenesis of gastric carcinoma
Hye Won Chung, Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 135-720, South Korea
Jong-Baeck Lim, Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul 135-720, South Korea
Author contributions: Chung HY and Lim JB designed the research; Chung HY and Lim JB performed research and analyzed the the data; and Chung HY and Lim JB wrote the paper.
Correspondence to: Jong-Baeck Lim, MD, PhD, Associate Professor, Department of Laboratory Medicine, Yonsei University College of Medicine, 50 Seodaemun-gu Seoul 135-720, South Korea. jlim@yuhs.ac
Telephone: +82-2-20193533 Fax: +82-2-20578926
Received: October 28, 2013
Revised: November 22, 2013
Accepted: December 5, 2013
Published online: February 21, 2014
Revised: November 22, 2013
Accepted: December 5, 2013
Published online: February 21, 2014
Core Tip
Core tip: The intensive interplay that exists between tumor cells and the tumor microenvironment can play an important role in tumor initiation, growth and metastasis. A better understanding of the molecular pathogenesis of the tumor microenvironment of Gastric carcinoma would be crucial for the design of novel molecular targets. In this review, we have provided an overview of the currently available knowledge of the role of the TME in gastric cancer and have highlighted the potential prognostic and therapeutic implications.