Ishiwatari H, Hayashi T, Yoshida M, Ono M, Masuko H, Sato T, Miyanishi K, Sato Y, Takimoto R, Kobune M, Miyamoto A, Sonoda T, Kato J. Phenol-based endoscopic ultrasound-guided celiac plexus neurolysis for East Asian alcohol-intolerant upper gastrointestinal cancer patients: A pilot study. World J Gastroenterol 2014; 20(30): 10512-10517 [PMID: 25132769 DOI: 10.3748/wjg.v20.i30.10512]
Corresponding Author of This Article
Hirotoshi Ishiwatari, MD, PhD, Assistant Professor, Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo 060-8543, Japan. ishihiro481019@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Aug 14, 2014; 20(30): 10512-10517 Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10512
Phenol-based endoscopic ultrasound-guided celiac plexus neurolysis for East Asian alcohol-intolerant upper gastrointestinal cancer patients: A pilot study
Hirotoshi Ishiwatari, Tsuyoshi Hayashi, Makoto Yoshida, Michihiro Ono, Tsutomu Sato, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato, Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, Sapporo 0600061, Japan
Tomoko Sonoda, Department of Public Health, Sapporo Medical University School of Medicine, Sapporo 0600061, Japan
Hiroyuki Masuko, Atsushi Miyamoto, Department of Hospital Pharmacy, Sapporo Medical University School of Medicine, Sapporo 0600061, Japan
Author contributions: Ishiwatari H designed the research; Ishiwatari H and Hayashi T performed the endoscopic procedure; Ishiwatari H, Hayahi T, Yoshida M, and Ono M collected the data and provided clinical advice; Masuko H and Miyamoto A prepared the neurolytic agent and provided clinical advice; Sato T, Miyanishi K, Sato Y, Takimoto R, Kobune M and Kato J provided clinical advise; Ishiwatari H and Sonoda T analyzed the data; Ishiwatari H wrote the paper; Hayashi T revised the paper; all authors approved the final manuscript for publication.
Correspondence to: Hirotoshi Ishiwatari, MD, PhD, Assistant Professor, Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo 060-8543, Japan. ishihiro481019@gmail.com
Received: February 19, 2014 Revised: April 14, 2014 Accepted: May 19, 2014 Published online: August 14, 2014
Core Tip
Core tip: We compared the pain-relieving effect and complications between endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN) using phenol on patients intolerant to alcohol and ethanol on patients without alcohol intolerance. Phenol had similar pain-relieving effects to ethanol; using phenol can avoid burning pain and inebriation complications. To date, few data regarding phenol-based EUS-CPN exist, and it is generally believed that phenol has a slightly slower onset and shorter duration of action than ethanol. Consequently, phenol is not routinely used in EUS-CPN. However, approximately half of East Asians lack mitochondrial aldehyde dehydrogenase activity, which causes alcohol intolerance. Our data provide evidence on phenol-based EUS-CPN for patients with alcohol intolerance.
