Role of non-coding RNAs in pancreatic cancer: The bane of the microworld

doi:10.3748/wjg.v20.i28.9405

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jul 28, 2014; 20(28): 9405-9417
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9405

Role of non-coding RNAs in pancreatic cancer: The bane of the microworld

Yi-Ting Tang, Xiao-Hui Xu, Xiao-Dong Yang, Jun Hao, Han Cao, Wei Zhu, Shu-Yu Zhang, Jian-Ping Cao

Yi-Ting Tang, Han Cao, Wei Zhu, Shu-Yu Zhang, Jian-Ping Cao, School of Radiation Medicine and Protection, Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, Jiangsu Province, China

Xiao-Hui Xu, Xiao-Dong Yang, Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China

Jun Hao, Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

Author contributions: Tang YT and Xu XH contributed equally to this work; Zhang SY, Cao JP and Zhu W designed the article; Tang YT, Xu XH and Yang XD wrote the paper; Hao J, Zhang SY and Cao H amended the paper.

Supported by National Natural Science Foundation of China, No. 81172597, No. 81102078, No. 81301933 and No. 81301764; and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

Correspondence to: Jian-Ping Cao, Professor, School of Radiation Medicine and Protection, Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Medical College of Soochow University, 199 Ren’ai Rd, Suzhou 215123, Jiangsu Province, China. jpcao@suda.edu.cn

Telephone: +86-512-65880065 Fax: +86-512-65880065

Received: October 25, 2013
Revised: February 12, 2014
Accepted: April 8, 2014
Published online: July 28, 2014

Core Tip

Core tip: The deregulation mechanisms of pancreatic cancer remain inscrutable. ncRNAs have recently been found to provide new opportunities for identifying both functional drivers and specific biomarkers of pancreatic cancer. Here, we review the expression profile of ncRNAs in human pancreatic cancer, with the aim of analyzing the feasibility of clinical application of ncRNA in pancreatic cancer’s diagnosis and treatment.