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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 7, 2014; 20(25): 8215-8220
Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.8215
Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.8215
Mesenchymal stem cell therapy in patients with small bowel transplantation: Single center experience
Sait Murat Doğan, Selçuk Kılınç, Eyüp Kebapçı, Cem Tuğmen, Mustafa Ölmez, Cezmi Karaca, Organ Transplantation Center, SB Tepecik Teaching and Research Hospital, 35121 Izmir, Turkey
Alp Gürkan, Organ Transplantation Center, Camlıca University Hospital, 34360 Istanbul, Turkey
Maşallah Baran, Department of Gastroenterology, SB Tepecik Teaching and Research Hospital, 35121 Izmir, Turkey
Yusuf Kurtulmuş, Tissue Typing Laboratory, SB Tepecik Teaching and Research Hospital, 35121 Izmir, Turkey
Author contributions: Dogan SM designed and performed the study, collected the data and wrote the paper; Kılınç S and Kebapçı E designed and performed the study, collected the data; Tuğmen C, Karaca C and Ölmez M performed the study and collected the data; Gürkan A analyzed the study, wrote and revised the paper; Baran M and Kurtulmuş Y collected the data.
Correspondence to: Alp Gürkan, MD, Organ Transplantation Center, Camlıca University Hospital, Burhaniye Mah, Yunus Emre Sok 18, 34360 Istanbul, Turkey. alpgurkan1@gmail.com
Telephone: +90-532-2667938 Fax: +90-532-2667938
Received: December 25, 2013
Revised: February 9, 2014
Accepted: April 2, 2014
Published online: July 7, 2014
Revised: February 9, 2014
Accepted: April 2, 2014
Published online: July 7, 2014
Core Tip
Core tip: Intestinal transplantation significantly improves prognosis and increases quality of life in patients with short gut syndrome. Transplantation of mesenchymal stem cells (MSCs) has been studied recently in animal models and in clinical trials of patients with hepatic failure, end-stage liver disease and inherited metabolic disorders. However, studies and data related to MSC therapy in small bowel transplantation are scarce. We think that MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation.