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World J Gastroenterol. Dec 21, 2013; 19(47): 9020-9033
Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9020
Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9020
Nrf2 and Snail-1 in the prevention of experimental liver fibrosis by caffeine
Daniela Gordillo-Bastidas, Edén Oceguera-Contreras, Adriana Salazar-Montes, Jaime González-Cuevas, Luis Daniel Hernández-Ortega, Juan Armendáriz-Borunda, Institute of Molecular Biology in Medicine and Gene Therapy/CUCS, University of Guadalajara, Guadalajara, Jalisco 44100, México
Author contributions: All the authors contributed to this manuscript.
Supported by Conacyt grant No. 25474 to Juan Armendáriz-Borunda
Correspondence to: Dr. Juan Armendáriz-Borunda, Institute of Molecular Biology in Medicine and Gene Therapy/CUCS, University of Guadalajara, Av. Juarez N 976, Centro, Guadalajara, Jalisco 44100, México. armdbo@gmail.com
Telephone: +52-33-10585317 Fax: +52-33-10585318
Received: May 17, 2013
Revised: June 19, 2013
Accepted: August 4, 2013
Published online: December 21, 2013
Revised: June 19, 2013
Accepted: August 4, 2013
Published online: December 21, 2013
Core Tip
Core tip: This paper shows the protective effect of caffeine in the liver to the constant aggressiveness of a hepatotoxic. Here we present evidence not published before of some molecular mechanisms like inhibition of Snail-1 and activation of Nrf2 that could be involved in this beneficial effect down-regulating pro-fibrogenic genes and up-regulating antioxidant molecules.