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World J Gastroenterol. Nov 14, 2013; 19(42): 7222-7230
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7222
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7222
Animal models of pancreatitis: Can it be translated to human pain study?
Jing-Bo Zhao, Dong-Hua Liao, Mech-Sense, Department of Gastroenterology and Surgery, Aalborg University Hospital, DK 9000 Aalborg, Denmark
Jing-Bo Zhao, Dong-Hua Liao, Institute of Clinical Medicine, Aarhus University, DK 8200 Aarhus N, Denmark
Jing-Bo Zhao, Dong-Hua Liao, The College of Bioengineering, Chongqing University, Chongqing 400016, China
Thomas Dahl Nissen, Biomedical Research Laboratory, Aalborg University Hospital, DK 9000 Aalborg, Denmark
Author contributions: Zhao JB, Liao DH and Nissen TD designed, drafted, revised and finally approved this paper.
Correspondence to: Jing-Bo Zhao, MD, PhD, Mech-Sense, Department of Gastroenterology and Surgery, Aalborg University Hospital, Sdr. Skovvej 15, DK 9000 Aalborg, Denmark. jz@rn.dk
Telephone: +45-9-9326907 Fax: +45-9-9326801
Received: June 13, 2013
Revised: August 12, 2013
Accepted: August 20, 2013
Published online: November 14, 2013
Revised: August 12, 2013
Accepted: August 20, 2013
Published online: November 14, 2013
Core Tip
Core tip: Choosing the right model of pancreatitis is difficult and the scientific rationale needs to be carefully considered. Furthermore, no model of pancreatitis parallels all classical symptoms and the question under investigation is of importance when choosing a model. One of the main symptoms of chronic pancreatitis is visceral pain and in order to improve the pain treatment and obtain more knowledge about the physiology behind the pancreatitis associated visceral pain, animal models of pancreatitis associated visceral pain are needed.