Brief Article
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World J Gastroenterol. Sep 14, 2013; 19(34): 5671-5677
Published online Sep 14, 2013. doi: 10.3748/wjg.v19.i34.5671
Eviendep® reduces number and size of duodenal polyps in familial adenomatous polyposis patients with ileal pouch-anal anastomosis
Carlo Calabrese, Chiara Praticò, Andrea Calafiore, Maurizio Coscia, Lorenzo Gentilini, Gilberto Poggioli, Paolo Gionchetti, Massimo Campieri, Fernando Rizzello
Carlo Calabrese, Chiara Praticò, Andrea Calafiore, Maurizio Coscia, Lorenzo Gentilini, Gilberto Poggioli, Paolo Gionchetti, Massimo Campieri, Fernando Rizzello, Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), University of Bologna, 40138 Bologna, Italy
Author contributions: Calabrese C initiated the study, coordinated the conduct of the whole study, performed the endoscopies; Calabrese C, Praticò C and Calafiore A prepared the draft of the manuscript; Calabrese C and Rizzello F re-evaluated all the endoscopy videos and photos in a blinded manner and scored the images separately; Coscia M, Gentilini L and Poggioli G performed the surgical procedures; Gionchetti P and Campieri M reviewed the manuscript; all authors approved the final version of the manuscript.
Correspondence to: Carlo Calabrese, MD, PhD, DIMEC, Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), University of Bologna, Via Massarenti 9, 40138 Bologna, Italy. carlo.calabrese2@unibo.it
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Received: April 29, 2013
Revised: June 13, 2013
Accepted: July 4, 2013
Published online: September 14, 2013
Core Tip

Core tip: Our open study demonstrated for the first time that short-term (90 d) supplementation with Eviendep® in familial adenomatous polyposis patients with ileal pouch-anal anastomosis and with recurrent adenomas in the duodenal mucosa, resulted effective in reducing polyps number of 32% and size of 51%. Eviendep® was easy to manage and its daily use was well tolerated by the patients. Its safety was guaranteed by its composition. Each ingredient is blended into the composition in a lower dose than the one otherwise needed for the single component to similarly exert the desired effect, thus leading to synergistic and/or potentiating effect, with the added advantage of higher safety, even over long-term exposure.