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World J Gastroenterol. Aug 14, 2013; 19(30): 4917-4924
Published online Aug 14, 2013. doi: 10.3748/wjg.v19.i30.4917
Published online Aug 14, 2013. doi: 10.3748/wjg.v19.i30.4917
Skp2-RNAi suppresses proliferation and migration of gallbladder carcinoma cells by enhancing p27 expression
Bin Zhang, Lin-Hua Ji, Wei Liu, Gang Zhao, Zhi-Yong Wu, Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
Author contributions: Zhang B, Zhao G and Wu ZY designed research; Zhang B, Ji LH and Liu W performed research; Zhang B and Ji LH analyzed data; Zhang B and Zhao G co-wrote the paper.
Correspondence to: Gang Zhao, MD, PhD, Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, No. 1630 Dongfang Road, Shanghai 200127, China. zhaogang74313@163.com
Telephone: +86-21-68383732 Fax: +86-21-68383090
Received: March 19, 2013
Revised: May 13, 2013
Accepted: June 8, 2013
Published online: August 14, 2013
Revised: May 13, 2013
Accepted: June 8, 2013
Published online: August 14, 2013
Core Tip
Core tip: The association between S-phase kinase-associated protein-2 (Skp2)/p27 and gallbladder carcinoma has rarely been reported. This study investigated the effects of Skp2-RNAi on in vitro and in vivo growth and the invasive potencies of gallbladder carcinoma cells. The authors proposed that the effects were due to the accumulation of the p27 protein following Skp2-depletion.