Liu BN, Liu XT, Liang ZH, Wang JH. Gut microbiota in obesity. World J Gastroenterol 2021; 27(25): 3837-3850 [PMID: 34321848 DOI: 10.3748/wjg.v27.i25.3837]
Corresponding Author of This Article
Ji-Hui Wang, PhD, Professor, School of Bioengineering, Dalian Polytechnic University, No. 1 Qinggongyuan, Dalian 116034, Liaoning Province, China. wangjh_dlpu@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jul 7, 2021; 27(25): 3837-3850 Published online Jul 7, 2021. doi: 10.3748/wjg.v27.i25.3837
Gut microbiota in obesity
Bing-Nan Liu, Xiao-Tong Liu, Zi-Han Liang, Ji-Hui Wang
Bing-Nan Liu, Xiao-Tong Liu, Zi-Han Liang, Ji-Hui Wang, School of Bioengineering, Dalian Polytechnic University, Dalian 116034, Liaoning Province, China
Ji-Hui Wang, Engineering Research Center of Health Food Design & Nutrition Regulation, Dongguan University of Technology, Dongguan 523808, Guangdong Province, China
Author contributions: Liu BN wrote the paper; Liu XT, Liang ZH, and Wang JH collected the data; all authors have read and approved the final manuscript.
Supported byThe Dalian Science and Technology Bureau, No. 2019RQ099; and the Department of Education of Liaoning Province, No. J2020097.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ji-Hui Wang, PhD, Professor, School of Bioengineering, Dalian Polytechnic University, No. 1 Qinggongyuan, Dalian 116034, Liaoning Province, China. wangjh_dlpu@163.com
Received: March 11, 2021 Peer-review started: March 11, 2021 First decision: April 5, 2021 Revised: April 14, 2021 Accepted: May 21, 2021 Article in press: May 21, 2021 Published online: July 7, 2021
Abstract
Obesity is a major global health problem determined by heredity and environment, and its incidence is increasing yearly. In recent years, increasing evidence linking obesity to the gut microbiota has been reported. Gut microbiota management has become a new method of obesity treatment. However, the complex interactions among genetics, environment, the gut microbiota, and obesity remain poorly understood. In this review, we summarize the characteristics of the gut microbiota in obesity, the mechanism of obesity induced by the gut microbiota, and the influence of genetic and environmental factors on the gut microbiota and obesity to provide support for understanding the complex relationship between obesity and microbiota. At the same time, the prospect of obesity research related to the gut microbiota is proposed.
Core Tip: Obesity is closely related to the gut microbiota. The study of the gut microbiome provides a basis for the reconstruction of the gut microbiota of obese patients. Here, we discuss the characteristics of the gut microbiota in obesity, the mechanism by which the gut microbiota induces obesity, and the relationships between genetic and environmental factors and the gut microbiota in obesity.
