Zhang L. Oral Campylobacter species: Initiators of a subgroup of inflammatory bowel disease? World J Gastroenterol 2015; 21(31): 9239-9244 [PMID: 26309350 DOI: 10.3748/wjg.v21.i31.9239]
Corresponding Author of This Article
Li Zhang, MBBS, PhD, Senior Lecturer (Medical Microbiology and Immunology), School of Biotechnology and Biomolecular Sciences, University of New South Wales, High St, Kensington, Sydney, NSW 2052, Australia. l.zhang@unsw.edu.au
Research Domain of This Article
Microbiology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Aug 21, 2015; 21(31): 9239-9244 Published online Aug 21, 2015. doi: 10.3748/wjg.v21.i31.9239
Oral Campylobacter species: Initiators of a subgroup of inflammatory bowel disease?
Li Zhang
Li Zhang, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Author contributions: Zhang L solely contributed to this paper.
Conflict-of-interest statement: The author has no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Li Zhang, MBBS, PhD, Senior Lecturer (Medical Microbiology and Immunology), School of Biotechnology and Biomolecular Sciences, University of New South Wales, High St, Kensington, Sydney, NSW 2052, Australia. l.zhang@unsw.edu.au
Telephone: +61-1-93852042 Fax: +61-2-93851483
Received: March 15, 2015 Peer-review started: March 16, 2015 First decision: April 23, 2015 Revised: May 8, 2015 Accepted: July 3, 2015 Article in press: July 3, 2015 Published online: August 21, 2015
Abstract
In recent years, a number of studies detected a significantly higher prevalence of Campylobacter species such as Campylobacter concisus (C. concisus) in intestinal biopsies and fecal samples collected from patients with inflammatory bowel disease (IBD) compared to controls. Most of these Campylobacter species are not of zoonotic origin but are human oral Campylobacter species. Bacterial species usually cause diseases in the location where they colonize. However, C. concisus and other oral Campylobacter species are associated with IBD occurring at the lower parts of the gastrointestinal tract, suggesting that these Campylobacter species may have unique virulence factors that are expressed in the lower parts of the gastrointestinal tract.
Core tip: The human oral cavity is a reservoir of a number of Campylobacter species. Accumulated evidence suggests that some oral Campylobacter species such as Campylobacter concisus may be initiators of a subgroup of human inflammatory bowel disease.
