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World J Gastroenterol. Jul 21, 2013; 19(27): 4445-4446
Published online Jul 21, 2013. doi: 10.3748/wjg.v19.i27.4445
Published online Jul 21, 2013. doi: 10.3748/wjg.v19.i27.4445
Word of caution before implementing ketotifen for gastrointestinal transit improvement
Kostan W Reisinger, Jacco J de Haan, Marc H Schreinemacher, Department of Surgery, Maastricht University Medical Center and NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, 6200 MD Maastricht, The Netherlands
Author contributions: Reisinger KW and Schreinemacher MH performed the majority of experiments; de Haan JJ was involved in setting up the study design and all authors were involved in writing and editing the manuscript.
Correspondence to: Kostan W Reisinger, MD, Department of Surgery, Maastricht University Medical Center and NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands. k.reisinger@maastrichtuniversity.nl
Telephone: +31-43-3882125 Fax: +31-43-3884154
Received: February 21, 2013
Revised: June 4, 2013
Accepted: June 8, 2013
Published online: July 21, 2013
Revised: June 4, 2013
Accepted: June 8, 2013
Published online: July 21, 2013
Abstract
The therapeutic potential of long-term ketotifen in irritable bowel syndrome and postoperative ileus is currently under investigation. Ambiguous results of prolonged postoperative ketotifen use on gastrointestinal passage have been found. The current data point at a hampered gastrointestinal transit after prolonged postoperative ketotifen use in a rodent ileus induction model. Therefore, caution should be taken when administering ketotifen in the perioperative phase.
Keywords: Ketotifen, Gastrointestinal transit, Postoperative ileus
Core tip: Prolonged postoperative ketotifen impairs gastrointestinal transit in a rodent ileus induction model.