Zhang LH, Li Q, Li P, Zhu ST, Wang J, Yang HL, Xu CQ, Guo XH. Association between gastric cancer and -1993 polymorphism of TBX21 gene. World J Gastroenterol 2012; 18(10): 1117-1122 [PMID: 22416188 DOI: 10.3748/wjg.v18.i10.1117]
Corresponding Author of This Article
Xiu-Hua Guo, Professor, School of Public Health and Family Medicine, Capital Medical University, No.10 Xitoutiao, You An Men, Beijing 100069, China. guoxiuh@ccmu.edu.cn
Article-Type of This Article
Brief Article
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Le-Hui Zhang, Xiu-Hua Guo, Department of Epidemiology and Health Statistics, School of Public Health and Family Medicine, Capital Medical University, Beijing 100069, China
Qin Li, Jing Wang, Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Le-Hui Zhang, Peng Li, Sheng-Tao Zhu, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Hong-Li Yang, Chang-Qing Xu, Department of Gastroenterology, Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China
Author contributions: Xu CQ and Guo XH designed the research; Zhu ST and Wang J performed the research; Zhang LH and Li Q analyzed the data; Li P and Yang HL wrote the paper.
Supported by National Natural Science Foundation, No.81000187
Correspondence to: Xiu-Hua Guo, Professor, School of Public Health and Family Medicine, Capital Medical University, No.10 Xitoutiao, You An Men, Beijing 100069, China. guoxiuh@ccmu.edu.cn
Telephone: +86-10-63131887 Fax: +86-10-66153395
Received: May 25, 2011 Revised: September 1, 2011 Accepted: September 8, 2011 Published online: March 14, 2012
Abstract
AIM: To investigate the association between the polymorphism of TBX21 gene and the risk of gastric cancer in a Chinese population.
METHODS: The -1993 polymorphism located in TBX21 gene promoter region was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The risk between TBX21 gene genotype and gastric cancer was determined by multivariate logistic regression analysis in 220 gastric cancer patients and 262 cancer-free controls matched by age, sex and ethnicity.
RESULTS: Compared with the TBX21 -1993TT genotype, the -1993CC genotype exhibited a significantly elevated risk for gastric cancer [Odds ratio (OR) = 3.42, 95% confidence interval (CI): 1.41-8.31]. The relationship between the -1993 polymorphic genotype and the invasive status such as lymph node and distant metastasis was found among the gastric cancer patients (OR = 4.02, 95% CI: 1.87-8.66; OR = 7.02, 95% CI: 3.44-14.34, respectively).
CONCLUSION: TBX21 -1993 polymorphism might contribute to the risk of gastric cancer, especially to the distant metastasis.
